The latest discovery from Sun et al. (2022) has revealed that IRI-induced AKI was attenuated by lncRNA TUG1 derived from USCs that inhibited acyl-CoA synthetase long-chain family member 4 (ASCL4)-mediated ferroptosis through interaction with serine/arginine splicing factor 1 (SRSF1). This evidence concerns the gene TUG1 and acute kidney injury.