CCN2 and renal fibrosis: Zhang et al. (2019) demonstrated in the mouse UUO model that serum miR-26a combated renal fibrosis by inhibiting connective tissue growth factor (CTGF). Moreover, Wang et al. (2016) observed that miR-let7c was transported to damaged kidney cells via sEVs from MSCs, thus slowing renal fibrosis progression.