Bai et al. (2020) demonstrated that circ_DLGAP4 was significantly upregulated in sEVs from high glucose-treated GMCs, which led to an increase in the progression of DKD by modulating miR-143/Erb-b2 receptor tyrosine kinase 3 (ERBB3)/nuclear factor-κB (NF-κB)/matrix metalloproteinase 2 (MMP2). Here, MMP2 is linked to diabetic kidney disease.