The epigenetic regulatory mechanisms of asthma include DNA methylation, and the methyl-CpG binding domain (MBD) family of proteins play a “reader” and regulatory role as a key bridge in the process of DNA methylation, and MBD2 is a member of the family (Horsburgh et al., 2015; Shen et al., 2020). This evidence concerns the gene MBD2 and asthma.