The IVW1 estimate showed that AF (OR = 1.001, 95% CI 1.000–1.002, P = 0.097), IS(OR = 1.001, 95% CI 1.000–1.001, P = 0.156), LIS(OR = 1.000, 95% CI 1.000–1.001, P = 0.524), PE(OR = 1.000, 95% CI 0.998–1.000, P = 0.210), HBP(OR = 1.000, 95% CI 0.998 1.002, P = 0.927), ISS (OR = 0.999, 95% CI 0.998–1.001, P = 0.430), HF(OR = 0.999, 95% CI 0.997–1.002, P = 0.584) were not associated with Lp(a). Here, LPA is linked to atrial fibrillation.