As a result, compared with stable plaque, there have differentially expressed genes (DEGs), there are 1034 up-regulated and 592 down-regulated genes in unstable plaque of atherosclerosis (Supplementary Excel1).According to adjust p-value, TM4SF19, DCSTAMP, MDFIC, LIPA, SVEP1, CCDC88A, DBI, VNN1, MMP12, ATP6V0D2 were ranked among the top 10 up-regulated DEGs (Table1, Fig. 1A); and viceSGCA, FBLN5, SCHIP1, NTF3, HABP4, ERBB2, CSDC2, CLEC18A, MFGE8, ARHGEF25-1 had the most significant changes in down-regulated DEGs (Table1, Fig. 1B). The gene discussed is FBLN5; the disease is atherosclerosis.