PCOS-HB patients (PCOS patients, BMI ≥ 24) had significantly higher LH, LH/FSH, AD, TT, dehydroepiandrosterone (DHEA), and FAI while lower SHBG than that of Healthy-HB subjects (FDR adjusted p < 0.05) (Fig. 1b, Table 1). The gene discussed is SHBG; the disease is polycystic ovary syndrome.