We also first discovered obvious interactions between natriuretic peptide precursor A (NPPA) and Nav1.5 through current summating research from the NCBI PubMed database using “NPPA and SCN5A (or Nav1.5, or sodium channel), natriuretic peptide precursor A and SCN5A (or Nav1.5, or sodium channel), ANP and SCN5A (or Nav1.5, or sodium channel), Brugada syndrome and NPPA (or ANP, or natriuretic peptide precursor A)”. Here, SCN5A is linked to Brugada syndrome.