The AIC-minimized models suggested a linear relationship between alcohol intake and HCC risk in all subgroups, although the HR estimates were statistically nonsignificant in men, subjects with abnormal ALT levels, and those carrying the CT/TT genotypes of TM6SF2 rs58542926 (Additional file 1: Figs. S11-S15 and Additional file 2: Table S7). Here, GPT is linked to hepatocellular carcinoma.