Silkworms contain 5006 genes that are highly homologous to human pathogenic genes [55] and have been developed as models for a variety of human diseases, including sepiapterin reductase deficiency [56], diabetes [57–59], gout [60], epilepsy [61], and other neurodegenerative diseases. Here, SPR is linked to hyperinsulinemic hypoglycemia, familial, 4.