The results showed that the gene enrichment pathways with the same expression trend of proteome and transcriptome were mainly enriched in neutral amino acid transport, response to viruses, the integrin-mediated signaling pathway, amino acid transport, the p53 signaling pathway, etc. The results indicated that Ttc39c might be involved in the progression of lung adenocarcinoma through these pathways. This evidence concerns the gene TTC39C and lung adenocarcinoma.