DNMT3A mutation happened in a variety of cancers such as colorectal cancer, lung cancer, chronic myelocytic leukemia, but is mainly with AML [32–34] and usually occur with other types of mutations, such as FLT3, NPM1, C/EBP alpha, resulting in synergistic effects in AML [35–37]. Here, NPM1 is linked to acute myeloid leukemia.