Huang D et al. reported that the oncogenic phosphatidylinositol 3-kinase (PIK3)/AKT pathway was abnormally activated in patients with PTCL and ENKTL, and a PI3K inhibitor induced cell cycle arrest but not the apoptosis in PTCL and ENKTL cells [35]. The gene discussed is AKT1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.