AKT1 and osteosarcoma: The AKT1 pathway was reported to be associated with chemoresistance in cancers [36, 37], overexpression of phosphor-AKT1 and AKT1 was observed in cisplatin-resistant cancer cells [38, 39], and downregulation of AKT was shown to reverse cisplatin resistance in osteosarcoma cells [40] and non-small‐cell lung cancer cells [41, 42].