PCNA and colorectal cancer: Besides, BI-2536 can inhibit MCM2 and MCM10 to suppress cell proliferation in neuroblastoma (Hsieh et al. 2021), metformin can deplete MCM2 and PCNA in 5-fluorouracil resistant colorectal cancer cells (Kim et al. 2017), norcantharidin can induce the degradation of MCM2 and CDC6 in HepG2 cells (Chen et al. 2013), ellagic acid can downregulate the expression of MCM2-7 in HepG2 (Qiu et al. 2021), widdrol can inhibit MCMs proteins in colon adenocarcinoma HT29 cells (Kwon et al. 2010), and TAK-931 can suppress the phosphorylation of MCM2 through targeting CDC7 (Iwai et al. 2019, 2021).