RNAi-mediated depletion of MCM2 induced G2/M-phase arrest in GBM and HCC cells (Hu et al. 2022; Qin and Tang 2004; Sun et al. 2010b), and G1-phase arrest in colon cancer and lung cancer cells (Wu et al. 2018; Liu et al. 2013; Cheung et al. 2017; Zhang et al. 2015). Here, MCM2 is linked to lung cancer.