For glioma, many glioma-associated targets, which are overexpressed in tumor cells compared to healthy tissue, or the so-called cancer-testis antigens, which are expressed in the germline, yet are invisible to the immune system due to lack of major histocompatibility complex (MHC) expression in this tissue, have been exploited as antigens for vaccination approaches. Here, HLA-C is linked to central nervous system cancer.