T cell transfer experiments in an intracranial breast cancer model using either i.v. or intratumoral Her2-specific CAR T cell injections showed antitumor responses, whereas at the same time, i.v. injections of IL13Rα2-directed CAR T cells were reported to have no effect in a glioblastoma model [144, 145]. Here, IL13RA2 is linked to glioblastoma.