Although the exact meaning of this staining remains unknown, the change of laminin expression pattern from linear at the basal cells in low-grade ED to cytoplasmic at the parabasal cells in high-grade ED/in situ carcinoma, not only demonstrates a surrogate biomarker for distinguishing these entities but probably indicates a shift of receptors and cell-cell adhesion molecules from BM to dysplastic epithelial cells, that might contribute to the degradation of the extracellular matrix at the beginning of an invasion. This evidence concerns the gene LAMB2 and cancer.