Vascular endothelial growth factor (VEGF) has been linked to the pathophysiology of stress-related psychiatric disorders, and plasma levels of ADEVs were positively correlated with soluble VEGF121 and soluble VEGFtotal levels in patients with stress-induced exhaustion disorder (SED) [53]. The gene discussed is VEGFA; the disease is spondyloepiphyseal dysplasia.