Because ASSR relies on the proper functioning of networks related to parvalbumin interneurons, changes in miR-137/COX6A2 plasma EV levels could be used as a proxy marker for dysfunction of the parvalbumin interneuron cortical microcircuit, which is implicated in the psychopathology and cognitive deficits of SCZ [34]. Here, PVALB is linked to Cognitive impairment.