What’s more, there were many studies suggesting that some cytokines might play a non-negligible role in the invasion of pancreatic cancer in bone, like type I collagen (1CTP)11, interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and parathyroid hormone-related protein (PTHrP)10. This evidence concerns the gene VEGFA and familial pancreatic carcinoma.