We further note that EPI-002, which produces small NMR CSPs consistent with an mM in vitro binding affinity and has a simulated mM KD value, has been shown to have ~10 μM IC50 value in prostate-specific antigen luciferase reporter assays for inhibition of endogenous AR transcriptional activity in cellular assays as well as clear anti-tumor activity in mouse models37. Here, KLK3 is linked to neoplasm.