Moreover, mutations affecting intronic regions present in more than 40% of the cases for the simple carcinomas but not found in the Cancer Mutation Census (Catalogue Of Somatic Mutations In Cancer = COSMIC) for HBC, were identified for ZNF511, DIAPH2, SORCS3, CNTNAP5, NFIA, ADGRL3, DGKB (Fig. 3a, genes specifically mutated in CMT). This evidence concerns the gene ADGRL3 and carcinoma.