MXD4 and acute myeloid leukemia: To determine whether SAP30 affects the function of AML cells, we performed the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) analysis and found that knockdown of SAP30 significantly decreased the proliferation of AML cells (Supplementary information, Fig. S6m), and the q-PCR and Western blotting analysis revealed that knocking down SAP30 significantly increased the expression of MXD4 in human and murine AML cells (Fig. 6i, j; Supplementary information, Fig. S5i).