Some genes that were dysregulated in AML cells with UHRF1 knockdown (e.g., MXD4, E2F1, E2F2, ILF2, LBR, POLD2, GINS1 and TXNIP) play vital roles in regulating these pathways (Fig. 4c). The gene discussed is MXD4; the disease is acute myeloid leukemia.