KMT2A and leukemia: Meanwhile, the Wright’s staining analysis revealed lots of leukemia blasts emerged in the peripheral blood (PB), bone marrow (BM) and spleen cells of AE9a/MLL-AF9Uhrf1fl/fl mice, whereas normal components of hematopoietic cells in AE9aUhrf1Δ/Δ mice and less leukemia blasts in MLL-AF9Uhrf1Δ/Δ mice were shown (Fig. 2f).