We performed flow cytometry analysis of LICs in BM cells of recipients with MLL-AF9-driven AML 4 weeks after Uhrf1 deletion by poly(I:C) administration, and found that Uhrf1 deletion significantly decreased the percentage of LICs from the recipient mice in the primary transplantation (Fig. 3g, h). The gene discussed is MLLT3; the disease is acute myeloid leukemia.