To further identify the role of UHRF1-regulated target genes in leukemia cells, we analyzed the DEGs from RNA-seq combined with the CUT&Tag data and found that there were 383 overlapped target genes in AML cells including MXD4 that encodes the transcriptional repressor MXD4, an antagonist of MYC39,40 (Fig. 4i). The gene discussed is MXD4; the disease is leukemia.