AKT1 and acute myeloid leukemia: Although the UHRF1 inhibitors Mitoxantrone and Hinokitiol inhibited the proliferation of AML cells, they also targeted USP11, PIM1 kinase, Snail or protein kinase B besides UHRF1 in cells.61–64 Although it has been reported that 4-BPC is the inhibitor of UHRF1, the chemical concentration of AML cell inhibition is much higher compared with UF146 (Supplementary information, Fig. S7c).