The results showed that Uhrf1 deficiency decreased the frequency of LICs in MLL-AF9- or AE9a-driven AML mice (1:10,949 vs 1:1478 cells and 1:3374 vs 1:747 cells, respectively) (Fig. 3j; Supplementary information, Fig. S3h). Here, KMT2A is linked to acute myeloid leukemia.