SAP30 and acute myeloid leukemia: To further understand the role of UHRF1 in leukemogenesis, we examined the proteins interacting with UHRF1 in AML cells by the mass spectrometry analysis and identified that UHRF1 bound to Sin3A-associated protein (SAP30), which mediates protein‒DNA interactions and is involved in transcriptional regulation (Supplementary information, Fig. S6a, b).42 Analysis of clinical samples showed that SAP30 was highly expressed in AML patients35,43 and AML cell lines (Supplementary information, Fig. S6c, d), and the high expression of SAP30 predicts the poor event-free survival in AML (Fig. 6a).