UHRF1 and acute myeloid leukemia: To further identify the role of UHRF1-regulated target genes in leukemia cells, we analyzed the DEGs from RNA-seq combined with the CUT&Tag data and found that there were 383 overlapped target genes in AML cells including MXD4 that encodes the transcriptional repressor MXD4, an antagonist of MYC39,40 (Fig. 4i).