Some genes that were dysregulated in AML cells with UHRF1 knockdown (e.g., MXD4, E2F1, E2F2, ILF2, LBR, POLD2, GINS1 and TXNIP) play vital roles in regulating these pathways (Fig. 4c). This evidence concerns the gene E2F2 and acute myeloid leukemia.