Gene ontology (GO) analysis of DEGs showed that GO terms or pathways such as the myeloid cell homeostasis, hemi-methylated DNA-binding, cell growth, apoptotic signaling, cell cycle-related pathways are highly enriched in AML cells upon UHRF1 knockdown (Supplementary information, Fig. S5b). This evidence concerns the gene UHRF1 and acute myeloid leukemia.