UHRF1 and acute myeloid leukemia: We also observed that UHRF1 inhibition induced inactivation of the MYC downstream target, E2F signaling, which was reported to contribute to the pathogenesis of myeloid malignancies.45 Consistent with our study, downregulating the MYC signature has been shown to decrease the self-renewal and proliferation of leukemic cells.46,47 It appears that decreased MYC signaling induced by UHRF1 inhibition confers a growth disadvantage to AML cells.