It was known that MYC binding with MAX stimulates the cell cycle progression and cell proliferation through regulation of E2F, and that MXD4 can inhibit MYC function by competing with MAX binding.39,41 We indeed found that E2F is decreased in AML cells with UHRF1 knockdown by the Western blotting analysis (Fig. 5e). Here, MXD4 is linked to acute myeloid leukemia.