MYC and acute myeloid leukemia: Furthermore, we applied the GSEA analysis to identify the pathways regulated by UF146 in AML cells and found the GSEA hallmark gene sets of the MYC targets, E2F targets, G2/M checkpoint and apoptosis signaling pathways were among top enriched gene sets that are regulated by UF146 (Fig. 7n; Supplementary information, Fig. S8i), which is consistent with the analysis about the pathways regulated by UHRF1.