ALB and liver disorder: The use of machine learning statistical approaches enabled us to confirm the results of prior studies that found similar baseline predictors of treatment failure, including factors associated with advanced liver disease or with treatment for advanced liver disease (e.g. use of immunosuppressants, diuretics, pain medication, or bile and liver therapies), PPI use, albumin level < 3.5 g/dL, total bilirubin level > 1.2 g/dL, and male sex, and predictors associated with treatment discontinuation21,22.