There were no changes in erythrocyte hemoglobin protein, erythrocyte size, or erythrocyte volume upon Cdh5-Cre–driven deletion (Supplementary Fig. 6); this is in contrast to the decreased erythrocyte volume and anemia in Hba1 global knockout animals (Hba1–/–, Supplementary Figs. 6 and 7). The gene discussed is HBA1; the disease is anemia.