CASP8 and neoplasm: In this regard, although ectopic over-expression of TRAIL-R2 may induce apoptosis in tumor cells growing in glutamine-containing medium (Fig. S3B) silencing FLIPL expression prior to ectopic TRAIL-R2 over-expression further increases caspase-8 activation and cell death by apoptosis under glutamine replete conditions (Fig. S3C, D).