Since the DISC components may colocalize in an intracellular membrane fraction in the absence of TRAIL [55], the increased expression of TRAIL-R2 and downregulation of cFLIP induced by glutamine deprivation in glutamine-addicted tumor cells could result in the formation of an intracellular DISC containing TRAIL-R2, FADD and procaspase-8 where caspase-8 is activated. This evidence concerns the gene CASP8 and neoplasm.