None of those circulating proteins had been reported as an inducer of insulin resistance, except for CHGA, a secretory protein that occurs in endocrine, neuroendocrine, and neuronal cells and is also a major cargo in insulin secretory vesicles in β cells [23–25], whose expression level was affected by the cytoplasmic localization of PTBP1 [22]. Here, CHGA is linked to Insulin resistance.