Runx2 is a transcription factor crucially controlling bone development (Kim et al, 2020) and also a facilitator of autophagy in different disease paradigms, such as osteogenesis, breast cancer, and vascular calcification (Yao et al, 2017; Qin & Cai, 2018; Tandon et al, 2018). This evidence concerns the gene RUNX2 and breast carcinoma.