AKT1 and obesity due to melanocortin 4 receptor deficiency: These compounds occur abundantly in plants and have been established to exhibit numerous therapeutic activities, namely antioxidant, antiviral, antifungal, anticancer, anti-inflammatory, antimicrobial, anti-allergic, analgesic, neuroprotective, antidiabetic, antihypertensive, cardioprotective, anti-obesity, antitumor, immunomodulatory, chemopreventive, as well as regulation of the PI3K/AKT signaling pathway, amongst others [72–76].