Our previous studies treating C57BL/10 mice with CSF-1R inhibitor PLX5622 beginning at either 14 or 80 dpi and continuing through terminal disease indicated that MG played a major role in prion disease survival following intracerebral inoculation of three distinct scrapie strains: RML, 22L and ME7 [22]. This evidence concerns the gene CSF1R and prion disease.