The first study was performed by Shen et al., reported that the plasma uromodulin levels are significantly diminished in LN or in IgA nephropathy compared to controls [17] and the second work was performed by Scherberich et al., identifying that SLE patients (n = 53) had lower sUromod levels than blood donors and children and these serum levels were even lower in the subgroup with lupus nephritis [16]. The gene discussed is UMOD; the disease is lupus nephritis.