SLE patients without renal flares had higher uromodulin levels and sUromod/eGFR index score than SLE patients with renal flares (130.9 ng/mL vs. 96.2 ng/mL, p<0.001; and 1.3 vs. 0.8, p<0.001, respectively). The gene discussed is UMOD; the disease is systemic lupus erythematosus.