In addition, we observed higher serum uromodulin levels in SLE patients with a proteinuria severity of stage 1 (<1.0 g/24 h) compared with a proteinuria severity of stage 2 (≥1.0 g/24 h) (p = 0.001), and higher sUromod/eGFR index scores (p = 0.001) (Fig 1). This evidence concerns the gene UMOD and systemic lupus erythematosus.