Third, we assessed the association of serum uromodulin levels and serum uromodulin levels adjusted by the eGFR with two renal disease activity indices, the rSLEDAI and the SLICC renal activity score, identifying that low serum uromodulin levels and a low sUromod/eGFR index score are associated with renal involvement. The gene discussed is UMOD; the disease is kidney disorder.