Table 4 shows the risk of renal flares, after adjusting for age, SLE disease duration, low C4 levels, low C3 levels, and anti-dsDNA antibody positivity, the logistic regression models showed that SLE patients with a low index score for serum uromodulin levels adjusted by the eGFR (sUromod/eGFR index score < 0.80) had an increased risk of renal flares identified by the renal SLEDAI (OR 2.91 95% CI 1.21 to 6.98; p = 0.02). This evidence concerns the gene C3 and systemic lupus erythematosus.