Disrupted-in-Schizophrenia-1 (DISC1), a candidate responsible gene for pathogenesis underlying schizophrenia, plays a role in the post-synaptic density associated with Rac1 [35] The transient and short-term depletion of DISC1 activates Rac1 and induces spine growth in primary cultured neurons. Here, DISC1 is linked to schizophrenia.