As insulin is a key regulator of both systemic and hepatic FA and glucose metabolism, dysregulation in insulin concentrations (i.e., hyperinsulinemia) and/or signaling (i.e., insulin resistance) often coincides with pathological IHTG accumulation, although whether it is the cause or consequence remains unclear (Pramfalk et al., 2016). This evidence concerns the gene INS and Hyperinsulinemia.