As insulin is a key regulator of both systemic and hepatic FA and glucose metabolism, dysregulation in insulin concentrations (i.e., hyperinsulinemia) and/or signaling (i.e., insulin resistance) often coincides with pathological IHTG accumulation, although whether it is the cause or consequence remains unclear (Pramfalk et al., 2016). Here, INS is linked to hyperinsulinism.