IRF1 and breast cancer: Besides, we ascertained subtype-specific profiles of TOFA, incorporating IFN-related genes (IFITM1, IFI30, IRF1, and IRF9) in naive and memory BCs, BC differentiation-related genes (CD38) in plasma BCs, HLA-DRA and CD74 in autoimmune-related BCs, and inflammation-related genes (S100A8, STAT1, and HLA-A) in 3 BC subsets (Figure 5G).