In this indication,a recent study showed that activation of the adenosine receptor 2Ausing the agonist CGS-21680 results in the depletion of CD11c+ Tbet+ B cells in both E. muris-infected and lupus-prone mice,68 makingit a strong candidate for targeted delivery using GNPs. Here, TBX21 is linked to systemic lupus erythematosus.