CD8A and neoplasm: CD8+ T cells can be metabolically reprogrammed to enhance oxidative phosphorylation (OXPHOS) by exogenous treatment with coenzyme A (CoA), by inducing the expression of glutamine transporters or supplementation with acetate to drive availability of acetyl-CoA in mitochondria to facilitate anti-tumor immunity (Song et al., 2018; St Paul et al., 2021).