IL13 and helminthiasis: While Th2 cell metabolism is regulated by mTOR and Akt and engages glycolysis (Delgoffe et al., 2009; Stark et al., 2019), ILC2s at barrier sites take up long-chain fatty acids and preferentially metabolize fatty acids to fuel OXPHOS through FAO, promoting IL-13 expression during helminth infections (Wilhelm et al., 2016).