In addition, a large amount of dietary n‐3/n‐6 PUFAs ameliorated obesity‐related insulin resistance and inflammation by inhibiting the activation of TLR4 in rats,16 prompting us to speculate whether n‐3 PUFAs could suppress depression by regulating TLR4 and its related signaling pathways. This evidence concerns the gene TLR4 and major depressive disorder.