Finally, the xenografts tumor model was established in vivo by injecting RBE cells with FoxM1 overexpression and we found that FoxM1 overexpression aggrandized tumor volume and weight, increased FoxP3 mRNA level the number of CD4+ CD25+ Treg cells and Ki67 level, but decreased the number of CD8+ T cells. This evidence concerns the gene CD4 and neoplasm.