In this study, FPR2 expression was significantly decreased in FCDIIb and TSC patients; moreover, FPR2 expression levels were negatively correlated with preoperative seizure frequency in FCDIIb and TSC patients, suggesting that FPR2 downregulation could result in the inadequate inflammation resolution that contributes to epilepsy in FCDIIb and TSC patients. The gene discussed is FPR2; the disease is tuberous sclerosis.