We have demonstrated that (1) immune‐restricted deficiency of C/EBPβ is associated with altered composition of myeloid cells populations in the liver at baseline, including reduced numbers of monocytes and Kupffer cells and increased numbers of MHC II positive myeloid cells; (2) immune cell deficient C/EBPβ mice exhibit weight gain retardation and mild spontaneous hepatitis; (3) in diet‐induced steatohepatitis model, immune‐restricted C/EBPβ deficiency was not associated with reduced steatosis, inflammation or fibrosis. This evidence concerns the gene CEBPB and hepatitis A virus infection.