However, patients with severe disease have lower IL‐38 concentrations than patients with mild disease. Furthermore, IL‐38 in COVID‐19 patients was negatively correlated with hospitalization duration, CRP, and the inflammatory marker lactate dehydrogenase (LDH), but not with SARS‐CoV‐2 viral load in sputum or nasopharyngeal swab specimen.23 This evidence concerns the gene IL1F10 and COVID-19.