On the contrary, the impact of JARID1 activation on the antitumor effect of DMC and curcumin is not clear because of the oncogenic and tumour suppressive functions of JARID1 proteins, which are contingent on the protein isoform (JARID1A, JARID1B, JARID1C, JARID1D) and cell context.37 Here, KDM5C is linked to neoplasm.