For instance, curcumin induced the mRNA and protein level of JMJD3 in human neuroblastoma cells with consequent decrease in H3K27me3 at the BDNF promoter region and increase in BDNF expression, suggesting a protective role of curcumin in Alzheimer's disease.25 Here, KDM6B is linked to early-onset autosomal dominant Alzheimer disease.