In the lastdecades, several classes of TSPO ligands endowed withanti-inflammatory and neuroprotective effects in both in vitro andin vivo models have been identified.14,20−23 In particular, TSPO ligands are proposed as therapeutic tools forAlzheimer’s disease,21 Parkinsondisease,10 multiple sclerosis,24 neuropathic pain,25 and anxiety disorders.26 The gene discussed is TSPO; the disease is glycogen storage disease VI.