CXCR4 and metastatic malignant neoplasm in the lymph nodes: In addition, multiple studies have shown that CXCR4 expression is frequently upregulated in oral squamous cell carcinomas (OSCCs) and that high CXCR4 expression is associated with lymph node metastasis, tumor recurrence, and a poor prognosis.7, 8, 9, 10