AGER and endothelial dysfunction: The main biochemical mechanisms implicated in the genesis ofhypertension in patients with diabetes include: increased formation of advancedglycation end products (AGEs), activation of the receptor for advanced glycationend products (AGER) (AGE-AGER axis), increased stress oxidative stress, chronicinflammation, endothelial dysfunction and activation of the renin-angiotensinsystem1, 4.