While tumor volume reconstruction (without correction for the necrotic area) did not show any significant difference between free BTZ and GO:BTZ groups (Figure 6C), using tissue structure‐based classification (Figure S9, Supporting Information)[64] we confirmed that the percentage of necrosis was significantly higher in the GO:BTZ group compared to free BTZ (Figure 6D) demonstrating an enhanced cytotoxic effect. This evidence concerns the gene CASC3 and neoplasm.