ACADM and hyperinsulinemic hypoglycemia, familial, 4: Medium‐Chain Acyl‐CoA Dehydrogenase (MCAD) is an enzyme key to the β‐oxidation of medium‐chain fatty acids (MCFAs).Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD) is the most common inherited metabolic disorder of β‐oxidation, in which patients have insufficient levels of functional MCAD.1