Furthermore, PBZ areas of different subtypes show differences in specific markers: the proneural margins contain mainly Olig2+/OPC‐like cells, which probably represent infiltrating glioma cells; the mesenchymal margins are enriched with genes expressed by microglia and CD44+ astrocytes; the classical margins contain a mixture of Olig2+ and CD44+ glioma cells (Gill et al., 2014) (Table 2). This evidence concerns the gene OLIG2 and central nervous system cancer.