IFNG and infection: Interestingly, while IL-6 acts as a negative regulator of IFN-γ in modulating T-cell activation [20], it has also been shown to be both necessary and sufficient to regulate IFN-γ-dependent immune responses to infection [21–24] and autoimmunity [25], suggesting a more complex relationship between these two cytokines that likely involve a number of cell types during the induction and resolution of inflammation.