Compared with other HTRA1 carriers, p.Arg227Trp carriers had reduced risk of any stroke (OR, 0.39; 95% CI, 0.20-0.79; P = .01) and ischemic stroke (OR, 0.28; 95% CI, 0.11-0.65; P = .003). This evidence concerns the gene HTRA1 and Stroke.