The presence of a COL4A1/2 variant was associated with increased risk of any stroke (OR, 1.67; 95% CI, 1.03-2.55; P = .04), which was accounted for by an increase in intracerebral hemorrhage risk (OR, 3.56; 95% CI, 1.34-7.53; P = .01), while there was no difference in ischemic stroke risk (OR, 1.16; 95% CI, 0.54-2.15; P = .69). This evidence concerns the gene COL4A1 and Stroke.