During follow-up for a median (IQR) duration of 12.6 years (11.8-13.2), NOTCH3 variants were associated with incident stroke (HR, 2.60; 95% CI, 1.87-3.50; P = 2.2 × 10−7) and vascular dementia (HR, 5.74; 95% CI, 3.02-9.77; P = 4.4 × 10−6) (Figure 2). This evidence concerns the gene NOTCH3 and stroke disorder.