Compared with other NOTCH3 carriers, EGFRs 1-6 carriers had increased risk of migraine (OR, 6.61; 95% CI, 2.14-17.89; P = .002), any stroke (OR, 14.01; 95% CI, 5.34-36.56; P = 6.6 × 10−7), ischemic stroke (OR, 13.78; 95% CI, 4.92-36.73; P = 5.7 × 10−6), vascular dementia (OR, 82.68; 95% CI, 22.49-358.03; P = 4.9 × 10−10) and all-cause dementia (OR, 46.19; 95% CI, 14.24-162.62; P = 3.0 × 10−9) but not of epilepsy (OR, 2.17; 95% CI, 0.23-9.46; P = .42) (Table 2). The gene discussed is NOTCH3; the disease is vascular dementia.