The presence of an HTRA1 variant was associated with increased risk of migraine with aura (OR, 10.36; 95% CI, 3.89-21.89; P = 7.6 × 10−5), any stroke (OR, 1.86; 95% CI, 1.30-2.59; P = .001), and ischemic stroke (OR, 2.01; 95% CI, 1.27-3.00; P = .004). Here, HTRA1 is linked to ischemic stroke.