In the contest of moderate-to-severe asthma, post-hoc analyses have been applied using accepted definitions for allergic asthma (skin prick–positive and/or positive serum–specific IgE >0.35 kU/L), eosinophilic asthma (B-EOS high count ≥300 cells/μL) and type-2 asthma (FENO ≥35 ppb). The gene discussed is IGHE; the disease is asthma.