Another study showed that 70% of patients with severe asthma had at least one type-2 biomarker elevated of which only 31% with a single biomarker, 39% with two or more elevated markers, and 15% had all three Type-2 biomarkers elevated (B-EOS count ≥0.3 x109/L; elevated FENO ≥25 ppb; elevated IgE ≥150 × 103). This evidence concerns the gene IGHE and asthma.