Moreover, Cheng et al. found that the microglial immune response mediated by the Notch1/NF-κB p65 pathway is the molecular mechanism by which FC deficiency aggravated neuronal cell death and microglial activation in the hippocampus after cerebral ischemia/reperfusion (Cheng et al., 2019). This evidence concerns the gene NOTCH1 and Cerebral ischemia.