We demonstrated significantly higher levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-7), anti-inflammatory cytokines (IL-1ra, IL-13), Th1 (INF-γ, IL-12, IL-2, IL-15), Th2 (IL-5, IL-6, IL-9), Th17 (IL-17), chemokines (MCP-1/CCL-2, MIP-1α/CCL3, MIP-1β/CCL4, EOTAXIN/CCL11, RANTES/CCL5, IL-8/CXCL8) and growth factors (GM-CSF, VEGF, FGF basic, PDFG-BB) in unstimulated saliva of HF patients compared to the controls. This evidence concerns the gene TNF and hydrops fetalis.