In addition, silencing the autophagy-associated protein BECLIN1 or VPS34 promotes the release of pro-inflammatory CCL5 and CXCL10 in the TME of melanoma and CRC tumor cells via activation of STAT1/IRF7 axis, resulting in increased infiltration of central immune effector cells (NK, CD8+ and CD4+ T cells, DC, and M1 macrophages). The gene discussed is PIK3C3; the disease is colorectal carcinoma.