Furthermore, Inhibition of autophagy in macrophages reprogrammed pro-tumor M2-like TAMs to a tumor-suppressing M1 phenotype that exerted anti-tumor effects by regulating not only NF-κB p65 protein homeostasis but also an IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 positive feedback loop (82, 83). This evidence concerns the gene IL6 and neoplasm.